Aquaporin-4 autoantibody (AQP4Ab) ELISA kit ELISA

  • Photography of AQP4 AB ELISA
  • Photography of AQP4 AB ELISA
The AQP4Ab kit is an accurate enzymatic assay used to measure AQP4 autoantibodies in human serum to identify autoimmune diseases of central nervous system.
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The AQP4Ab kit is an accurate enzymatic assay used to measure AQP4 autoantibodies in human serum to identify autoimmune diseases of central nervous system.
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Overview

Diagnosis neuromyelitis optica (NMO / Devic’s syndrome) or neuromyelitis optica spectrum disorder (NMOSD)

Distinguish NMOSD from multiple sclerosis (MS) at an early stage of the disease

Benefits

  • ACCURATE AND RELIABLE ENZYMATIC ASSAY

Assay principle: sandwich

AQP4 molecules are coated onto the ELISA plate wells. AQP4-biotin complexes constitute the liquid phase. AQP4 Ab from the sample will bind to the AQP4 coated on the well and interact with AQP4-biotin to form a bridge. The bound AQP4-biotin is detected through the addition of streptavidin peroxidase (SA-POD). The unbound SA-POD in excess is washed off before addition of the peroxidase substrate TMB.

Assay procedure: 2h at RT / shaking + 20 min at RT / shaking + 20 min at RT in the dark.

Features

Working range: 1.5 – 80 U/mL

Sample: serum – 50 µL

Analytical sensitivity: 0.17 U/mL

Normal values

Samples from 216 presumably healthy blood donors were analyzed. 100% were identified as being negative for AQP4 autoantibodies.